1584-62-9

Basic information

• Product Name: 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide
• Synonyms: 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide;2-BROMO-4''-CHLORO-2''-(2-FLUOROBENZOYL)ACETANILIDE;2-(2-Bromoacetamido)-5-chloro-2''-fluorobenzophenone;2-BroMoacetaMido-5-chloro-2'-fluorobenzophenone;2-BroMo-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetaMide;5-Chloro-2-(broMoacetylaMino)-2'-fluorobenzophenone
• CAS NO: 1584-62-9
• Molecular Formula: C₁₅H₁₀BrClFNO₂
• Molecular Weight: 370.6008032
• EINECS: 216-437-7
• Product Categories: Aromatics;Heterocycles
• Mol File: 1584-62-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 132-133℃
• Boiling Point: 575.2°Cat760mmHg
• Flash Point: 301.7°C
• Appearance: /
• Density: 1.611
• Vapor Pressure: 0Pa at 25℃
• CAS DataBase Reference: 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide(1584-62-9)
• EPA Substance Registry System: 2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide(1584-62-9)

Safety Data

• Hazardous Substances Data: 1584-62-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

Uses

N-[2-(2-Fluorophenyl)-4-chlorophenyl-2-bromoacetamide (cas# 1584-62-9) is a compound useful in organic synthesis.

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 
• 106-47-8 4-chloro-aniline 
• 393-52-2 2-Fluorobenzoyl chloride 

Downstream Products

• 32708-98-8 10-chloro-11b-(2-fluoro-phenyl)-3-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 2886-65-9 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one 
• 713517-39-6 7-chloro-5-(2-fluoro-phenyl)-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 39256-30-9 2-(methylthio)-5-(o-fluorophenyl)-7-chloro-3H-1,4-benzodiazepine 
• 1645-32-5 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-thione 
• 59467-70-8 Midazolam 

Relevant articles and documents

Axially chiral Ni(II) complexes of α-amino acids: Separation of enantiomers and kinetics of racemization

Herein we present design, synthesis, chiral HPLC resolution, and kinetics of racemization of axially chiral Ni(II) complexes of glycine and di-(benzyl)glycine Schiff bases. We found that while the ortho-fluoro derivatives are configurationally unstable, t

Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists

Since its discovery in 1988 by Yanagisawa et al., endothelin (ET), a potent vasoconstrictor, has been widely implicated in the pathophysiology of cardiovascular, cerebrovascular, and renal diseases. Many research groups have embarked on the discovery and development of ET receptor antagonists for the treatment of such diseases. While several compounds, e.g., ambrisentan 2, are in late clinical trials for various indications, one compound (bosentan, Tracleer) is being marketed to treat pulmonary arterial hypertension. Inspired by the structure of ambrisentan 2, we designed a novel class of ET receptor antagonists based on a 1,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-one scaffold. Here, we report on the preparation as well as the in vitro and in vivo structure-activity relationships of these derivatives. Potent dual ET A/ETB receptor antagonists with affinities in the low nanomolar range have been identified. In addition, several compounds efficiently reduced arterial blood pressure after oral administration to Dahl salt sensitive rats. In this animal model, the efficacy of the benzo[e] [1,4]diazepin-2-one derivative rac-39au was superior to that of racemic ambrisentan, rac-2.