158457-36-4

Basic information

• Product Name: 1H-Indole-1,2-dicarboxylic acid, 2,3-dihydro-, 1-(1,1-dimethylethyl) 2-methyl ester, (R)-
• CAS NO: 158457-36-4
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Mol File: 158457-36-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1,2-dicarboxylic acid, 2,3-dihydro-, 1-(1,1-dimethylethyl) 2-methyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1,2-dicarboxylic acid, 2,3-dihydro-, 1-(1,1-dimethylethyl) 2-methyl ester, (R)-(158457-36-4)
• EPA Substance Registry System: 1H-Indole-1,2-dicarboxylic acid, 2,3-dihydro-, 1-(1,1-dimethylethyl) 2-methyl ester, (R)-(158457-36-4)

Safety Data

• Hazardous Substances Data: 158457-36-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98167-06-7 (R)-(-)-2,3-Dihydro-1H-Indole-2-Carboxylic Acid 
• 186704-03-0 methyl (+/-)-1-t-butoxycarbonyl-indoline-2-carboxylate 
• 67-63-0 isopropyl alcohol 
• 163229-48-9 1-(1,1-dimethylethyl)-1H-indole-1,2-dicarboxylic acid 2-methyl ester 

Relevant articles and documents

Enantioselective hydrogenation of indoles derivatives catalyzed by Walphos/rhodium complexes

The enantioselective hydrogenation of indole esters has been carried out efficiently in the presence of a rhodium catalyst modified by Walphos-type chiral ligands. The addition of a base can be beneficial in some catalytic conditions.

Total synthesis of (+)-benzastatin E via diastereoselective Grignard addition to 2-acylindoline.

[reaction: see text] A stereoselective total synthesis of (+)-benzastatin E (1) is described. The synthesis involves a diastereoselective Grignard addition to 2-acylindoline 2, which is derived from commercially available (S)-2-indolinecarboxylic acid (3). The unknown absolute configuration of (+)-1 is determined as (9S,10R).