158462-50-1

Basic information

• Product Name: R(+)-3-(trifluoroacetamido)butanoic acid
• Synonyms: R(+)-3-(trifluoroacetamido)butanoic acid
• CAS NO: 158462-50-1
• Molecular Weight: 199.13
• Mol File: 158462-50-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: R(+)-3-(trifluoroacetamido)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: R(+)-3-(trifluoroacetamido)butanoic acid(158462-50-1)
• EPA Substance Registry System: R(+)-3-(trifluoroacetamido)butanoic acid(158462-50-1)

Safety Data

• Hazardous Substances Data: 158462-50-1(Hazardous Substances Data)

Upstream product

• 3775-73-3 (R)-3-aminobutanoic acid 
• 383-63-1 ethyl trifluoroacetate, 

Relevant articles and documents

Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative

A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.