1585214-88-5

Basic information

• Product Name: (S)-2-(ethoxycarbonyl)-1-(2-m-tolylthiazol-4-yl)ethyl butanoate
• Synonyms: (S)-2-(ethoxycarbonyl)-1-(2-m-tolylthiazol-4-yl)ethyl butanoate
• CAS NO: 1585214-88-5
• Molecular Weight: 361.462
• Mol File: 1585214-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-(ethoxycarbonyl)-1-(2-m-tolylthiazol-4-yl)ethyl butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(ethoxycarbonyl)-1-(2-m-tolylthiazol-4-yl)ethyl butanoate(1585214-88-5)
• EPA Substance Registry System: (S)-2-(ethoxycarbonyl)-1-(2-m-tolylthiazol-4-yl)ethyl butanoate(1585214-88-5)

Safety Data

• Hazardous Substances Data: 1585214-88-5(Hazardous Substances Data)

Upstream product

• 1585214-72-7 rac-2-(ethoxycarbonyl)-1-(2-m-tolylthiazol-4-yl)ethyl butanoate 
• 92422-79-2 2-m-tolyl-thiazole-4-carbaldehyde 
• 1585214-68-1 rac-ethyl 3-hydroxy-3-(2-m-tolylthiazol-4-yl)propanoate 

Relevant articles and documents

Heterocycles 35. CaL-B mediated synthesis of enantiomerically pure (R)- and (S)-ethyl 3-(2-arylthiazol-4-yl)-3-hydroxypropanoates

Herein we present the lipase catalyzed synthesis of four new enantiomerically pure (R)- and (S)-ethyl 3-(2-arylthiazol-4-yl)-3- hydroxypropanoates and their butanoates by enzymatic enantioselective acylation of the racemic alcohols rac-1a-d and by ethanolysis of the corresponding racemic esters rac-2a-d mediated by lipase B from Candida antarctica (CaL-B) in organic solvents. In terms of stereoselectivity and activity, both procedures, the acylation and alcoholysis, are successful (50% conversion, E ? 200). The absolute configuration of the resolution products was determined by a detailed 1H NMR study of the Mosher's derivatives of (S)-1a.