158558-35-1

Basic information

• Product Name: (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone
• Synonyms: (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone
• CAS NO: 158558-35-1
• Molecular Weight: 218.175
• Mol File: 158558-35-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone(158558-35-1)
• EPA Substance Registry System: (+/-)-α-hydroxy-4-(trifluoromethyl)propiophenone(158558-35-1)

Safety Data

• Hazardous Substances Data: 158558-35-1(Hazardous Substances Data)

Upstream product

• 95728-57-7 2-bromo-1-(4-trifluoromethylphenyl)propan-1-one 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 711-33-1 4-trifluoromethyl propiophenone 
• 67081-98-5 (+/-)-1-<4-(trifluoromethyl)phenyl>-1-propanol 
• 75-07-0 acetaldehyde 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 158647-85-9 α-(tetrahydropyran-2-yloxy)-4-(trifluoromethyl)propiophenone 
• 150803-04-6 (+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane 

Relevant articles and documents

Green preparation method α - hydroxyketone

The invention relates to a green preparation method of alpha-hydroxyketone. The method comprises the following steps: adding ketone, iodine, 1,4-diazabicyclo[2.2.2]octane and methanol into a glass reaction bottle in sequence; then stirring and reacting for 14 to 30h at room temperature in an air atmosphere under the irradiation of a 23W compact type fluorescent lamp, so as to obtain a reaction mixture; carrying out silica gel column chromatographic separation to obtain the pure alpha-hydroxyketone. The green preparation method provided by the invention has the characteristics of greenness, high efficiency, simplicity in operation, moderate conditions, wide applicability and easiness for industrialization.

Switching regioselectivity in crossed acyloin condensations between aromatic aldehydes and acetaldehyde by altering n -heterocyclic carbene catalysts

An unprecedented high level of regioselectivities (up to 96%) in the intermolecular crossed acyloin condensations of various aromatic aldehydes with acetaldehyde was realized by an appropriate choice of N-heterocyclic carbene catalysts.(Figure Presented)

Orally active azole derivatives

The present invention relates to new orally active azole derivatives with antifungal activity of formula I STR1 wherein: X is CH or N; Ar represents phenyl substituted with halogen and/or trifluoromethyl; Z is --C(=O)-- or --SO2 --; R1 is CN, CO2 H, CO2 R7, CONR8 R9 or CH2 Y and then R3 is hydrogen, or R1 together with R3 forms a ring of formula I' STR2 wherein B is O, hydroxy or hydrogen; R4 is C1-4 alkyl; R5, R6, R8 and R9 are hydrogen or C1-4 alkyl; Y is --OH, --OR7, --OC(=O)R7, --NR8 R9, --NHC(=O)OR7 ; R7 is C1 -C4 -alkyl, phenyl-C1 -C4 -alkyl or optionally substituted phenyl; when Z is --C(=O)--, R2 is optionally susbtituted phenyl, or naphtyl; when Z is --SO2 --, R2 is C1-4 alkyl, phenyl-C1-4 -alkyl or optionally susbtituted phenyl.