158563-45-2 Usage
Description
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, also known as Nonapeptide-1, is a skin lightening peptide derived from the melanocyte stimulating hormone (MSH). It possesses the ability to inhibit the activity of tyrosine in melanocytes, leading to the suppression of melanin synthesis. This peptide helps in evening out skin tone by reducing hyper-pigmentation, thus controlling skin tone and brown spots.
Uses
1. Used in Skin Care Products:
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 is used as a skin whitening agent for its ability to inhibit melanin synthesis and reduce hyper-pigmentation, leading to an even skin tone and a decrease in brown spots.
2. Used in Pharmaceutical Industry:
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 is used as a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist with an IC50 of 11 nM. It helps in reducing the synthesis of melanin and decreasing skin pigmentation to a substantial degree, making it a valuable component in the development of skin radiance and anti-dark spot treatments.
3. Used in Cosmeceuticals:
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 is used as an active ingredient in cosmeceutical products aimed at skin lightening, whitening, and anti-dark spot applications, providing consumers with a natural and effective solution for improving skin tone and reducing the appearance of pigmentation issues.
benefits
Nonapeptide-1inhibits melanin production originally induced bya-MSH.Whitening, spot-removing as well as preventing hyperpigmentation.Its recommended dosage in skin care products is 0.5~3%.
Biological Functions
1. Inhibit melanin synthesis by interfering with the action of tyrosinase in melanocytes. Reduce hyperpigmentation and lighten darker areas that have been damaged by the sun and certain diseases.2. Interfer with melanocyte stimulating hormone (MSH). MSH increases during pregnancy, as a result of certain medical conditions (e.g. diabetes, Addison’s disease), and as a result of excessive sun exposure.3. Nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin in fungi.4. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%
storage
Common storage 2-8℃, long time storage -20℃.
Check Digit Verification of cas no
The CAS Registry Mumber 158563-45-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,5,6 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 158563-45:
(8*1)+(7*5)+(6*8)+(5*5)+(4*6)+(3*3)+(2*4)+(1*5)=162
162 % 10 = 2
So 158563-45-2 is a valid CAS Registry Number.