158583-41-6

Basic information

• Product Name: 3-(m-Tolyl)-3-phenyl-3-hydroxy-propin-⁽¹⁾
• CAS NO: 158583-41-6
• Molecular Weight: 222.287
• Mol File: 158583-41-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(m-Tolyl)-3-phenyl-3-hydroxy-propin-⁽¹⁾(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(m-Tolyl)-3-phenyl-3-hydroxy-propin-⁽¹⁾(158583-41-6)
• EPA Substance Registry System: 3-(m-Tolyl)-3-phenyl-3-hydroxy-propin-⁽¹⁾(158583-41-6)

Safety Data

• Hazardous Substances Data: 158583-41-6(Hazardous Substances Data)

Upstream product

• 643-65-2 3-methyl benzophenone 
• 4301-14-8 acetylenemagnesium bromide 
• 70277-75-7 lithium acetylide 

Downstream Products

• 20921-49-7 N-Cyclohexyl-carbaminsaeure-<3-(m-tolyl)-3-phenyl-propin-(1)-yl-(3)>-ester 

Relevant articles and documents

Synthesis of Organophosphorus Compounds through Copper-Catalyzed Annulation Involving C-O and C-P Bond Formations

A novel copper(II) trifluoromethanesulfonate-catalyzed, high-efficiency, and atom-economical synthesis of valuable organophosphorus compounds via cascade annulation of propargylic alcohols with diphenylphosphine oxide is described. This protocol, which has a good functional-group compatibility and insensitivity to an ambient atmosphere, provides a simple and direct pathway to the products, organophosphorus compounds, in good yields under mild conditions. The method could be efficiently scaled up to gram scale, thus highlighting a potential application of this methodology.