15865-18-6

Basic information

• Product Name: N-CYCLOHEXYL-5-CHLOROVALERAMIDE
• Synonyms: N-CYCLOHEXYL-5-CHLOROVALERAMIDE;N-5-CHLOROVALERYL CYCLOHEXYLAMINE;5-CHLORO-N-CYCLOHEXYLPENTANAMIDE;5-Chloro-N-cyclohexylvaleraMide;5-Chloro-N-cyclohexyl-valeraMide;N-Cyclohexyl-5-chloropentanaMide
• CAS NO: 15865-18-6
• Molecular Formula: C₁₁H₂₀ClNO
• Molecular Weight: 217.74
• Product Categories: Miscellaneous Reagents
• Mol File: 15865-18-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 383.608 °C at 760 mmHg
• Flash Point: 185.8 °C
• Appearance: /
• Density: 1.043 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.482
• PKA: 15.98±0.20(Predicted)
• CAS DataBase Reference: N-CYCLOHEXYL-5-CHLOROVALERAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOHEXYL-5-CHLOROVALERAMIDE(15865-18-6)
• EPA Substance Registry System: N-CYCLOHEXYL-5-CHLOROVALERAMIDE(15865-18-6)

Safety Data

• Hazardous Substances Data: 15865-18-6(Hazardous Substances Data)

Usage

Description

N-CYCLOHEXYL-5-CHLOROVALERAMIDE, also known as 5-Chloro-N-cyclohexylpentanamide (CAS number 15865-18-6), is an organic compound with a chemical structure that features a cyclohexyl group and a chloro substituent. It is an off-white solid and is primarily used in the field of organic synthesis due to its unique chemical properties.

Uses

Used in Organic Synthesis:
N-CYCLOHEXYL-5-CHLOROVALERAMIDE is used as a synthetic intermediate for the development of various organic compounds. Its unique chemical structure allows it to be a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-CYCLOHEXYL-5-CHLOROVALERAMIDE is used as a key component in the synthesis of new drug candidates. Its cyclohexyl and chloro substituents can be exploited to create novel molecular structures with potential therapeutic applications.
Used in Agrochemical Industry:
N-CYCLOHEXYL-5-CHLOROVALERAMIDE is also utilized in the agrochemical industry for the development of new pesticides and other crop protection agents. Its chemical properties can be tailored to target specific pests or diseases, contributing to the creation of more effective and environmentally friendly products.
Used in Specialty Chemicals:
In the specialty chemicals sector, N-CYCLOHEXYL-5-CHLOROVALERAMIDE is employed as a starting material for the synthesis of various high-value compounds. These can include additives for the plastics and coatings industries, as well as components for advanced materials with specific properties, such as improved thermal stability or enhanced electrical conductivity.

InChI:InChI=1/C11H20ClNO/c12-9-5-4-8-11(14)13-10-6-2-1-3-7-10/h10H,1-9H2,(H,13,14)

Upstream product

• 1575-61-7 5-Chlorovaleroyl chloride 
• 108-91-8 cyclohexylamine 
• 6280-87-1 δ-chlorovaleronitrile 
• 108-93-0 cyclohexanol 

Downstream Products

• 73963-42-5 1-cyclohexyl-5-(4-chlorobutyl)-1,2,3,4-tetrazole 
• 4856-18-2 1-cyclohexyl-piperidin-2-one 

Relevant articles and documents

Synthesis method of N-cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole

The invention discloses a synthesis method of N-cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole. The synthesis method comprises the following steps: firstly, synthesizing N, N-dimethylformamide; the synthesis method comprises the following synthesis steps: taking 5-chlorovaleronitrile and cyclohexanol as raw materials, controlling the molar ratio of the 5-chlorovaleronitrile to the cyclohexanol to be (1: 1)-(1: 1.5) and the reaction temperature to be 5-55 DEG C, and carrying out a catalytic reaction for 1-6 hours by virtue of concentrated sulfuric acid, so as to obtain 5-chloro-N-cyclohexylvaleramide; wherein the molar ratio of the 5-chlorovaleronitrile to the concentrated sulfuric acid for catalysis is (1: 3)-(1: 10); the preparation method comprises the following steps: treating 1, 5-chloro-N-cyclohexylvaleric amide with phosphorus pentachloride; wherein the molar ratio of the 3, 5-chloro-N-cyclohexylvaleric amide to the phosphorus pentachloride is (1: 1)-(1: 1.5) and the molar ratio of the 2, 5-chloro-N-cyclohexylvaleric amide to the phosphorus pentachloride is (1: 1)-(1: 1.5); according to the invention, trimethyl silicon azide is used as a cyclization reagent instead of azoic acid or sodium azide, so that the synthesis method has the advantages of higher stability, no explosion and higher safety, the cost can be effectively reduced, the synthesis method is environment-friendly,and the purity of the obtained product is high.

CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention compositions containing these compounds for the treatment of metabolic syndrome, diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula I wherein G1 is methylene or ethylene; L is-(C1-C4)alkylene-, -S-, -CH(OH)-, or -O-; R0 is Formula II or Formula III and the other substituents are as defined in the claims.