1586765-14-1

Basic information

• Product Name: 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide
• Synonyms: 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide
• CAS NO: 1586765-14-1
• Molecular Weight: 393.421
• Mol File: 1586765-14-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide(1586765-14-1)
• EPA Substance Registry System: 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide(1586765-14-1)

Safety Data

• Hazardous Substances Data: 1586765-14-1(Hazardous Substances Data)

Upstream product

• 31802-54-7 1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 
• 88958-25-2 5-methyl-1-(4-methoxyphenyl)-1,2,3-triazol-4-carbonyl chloride 
• 2711-58-2 5-Fluorotryptamine hydrochloride 

Downstream Products

• 1586765-20-9 1-[5-methyl-1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-6-fluoro-4,9-dihydro-3H-β-carboline 

Relevant articles and documents

Synthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives

Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbocylic acid chlorides with tryptamine derivatives afforded substituted 1-aryl-N-[2-(1H-indol-3-yl) ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. At heating these compounds in toluene in the presence of POCl3 and P2O5 Bischler-Napieralski cyclization occurs giving 1-(1-aryl-5-methyl-1H-1,2,3- triazol-4-yl)-4,9-dihydro-3H-β-carbolines that can be transformed into β-carboline and tetrahydro-β-carboline derivatives.