158800-64-7Relevant articles and documents
Preparation of difluoro analogs of CCGs and their pharmacological evaluations
Shibuya, Akira,Sato, Azusa,Taguchi, Takeo
, p. 1979 - 1984 (2007/10/03)
All the stereoisomers of 2-(2-carboxy-3,3-difluorocyclopropyl)glycines (F2CCGs) were synthesized in enantiomerically pure forms using (R)-2,3-O- isopropyl-ideneglyceraldehyde as a chiral precursor. L-F2CCG-I, one of the stereoisomers
ASYMMETRIC SYNTHESIS OF DIFLUOROCYCLOPROPANES
Taguchi, Takeo,Shibuya, Akira,Sasaki, Hirofumi,Endo, Jun-ichi,Morikawa, Tsutomu,Shiro, Motoo
, p. 1423 - 1426 (2007/10/02)
A highly diastereoselective synthesis of functionalized trans gem-difluorocyclopropane carboxylate 3 was achieved through sequential Michael addition of lithium enolate of homochiral N-acylimidazolidinone 2 with 2,4,6-trimethylphenyl (TMP) 4-bromo-4,4-dif