15884-86-3

Basic information

• Product Name: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE)
• Synonyms: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE);1,3,4-Thiadiazol-2-amine, 5-(methoxymethyl)- CAS NO:15884-86-3
• CAS NO: 15884-86-3
• Molecular Formula: C₄H₇N₃OS
• Molecular Weight: 145.18288
• Mol File: 15884-86-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 279.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.359±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.90±0.10(Predicted)
• CAS DataBase Reference: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE)(15884-86-3)
• EPA Substance Registry System: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE)(15884-86-3)

Safety Data

• Hazardous Substances Data: 15884-86-3(Hazardous Substances Data)

Usage

General Description

5-(methoxymethyl)-1,3,4-thiadiazol-2-amine, also known as SALTDATA: FREE, is a chemical compound with the molecular formula C5H8N4OS. It is a thiadiazole amine derivative and is commonly used as a building block in organic synthesis and pharmaceutical research. The compound has potential biological activities and is being studied for its therapeutic applications in the treatment of various diseases. This chemical has attracted attention due to its structural features and potential pharmacological properties, and ongoing research is aimed at further understanding its biological functions and potential medical uses.

Upstream product

• 79-19-6 thiosemicarbazide 
• 13779-42-5 chlorophosphoric acid 
• 625-45-6 2-methoxyacetic acid 

Downstream Products

• 61450-91-7 5-bromo-2-methoxymethyl(1,3,4)thiadiazole 
• 1420066-22-3 3-(methoxymethyl)-1-(2-nitrophenyl)-1H-1,2,4-triazol-5-amine 

Relevant articles and documents

Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification

Multifaceted roles of vascular endothelial growth factor (VEGF)-neuropilin-1 (NRP1) interaction have been implicated in cancer, but reports on small-molecule inhibitors of VEGF-NRP1 interaction are scarce. Herein, we describe the identification of 1, a novel nonpeptide small-molecule NRP1 antagonist with moderate activity via structure-based virtual screening. Ensemble docking and molecular dynamics (MD) simulations of 1 were carried out and an interesting binding model was obtained. We found that the “aromatic box” enclosed by Tyr297, Trp301 and Tyr353 of NRP1 is critical for NRP1-1 binding. Further structure modification of 1 based on the binding model derived from MD simulations resulted in the identification of 12a with significantly improved activity.

CERTAIN NITROGEN HETEROCYCLIC ISOTHIOCYANATE ESTERS

Process for preparing thioureas by treating isothiocyanates with ammonia and alkylamines. A specific product is N-methyl-N'-2-((5-methyl-4-imidazolyl)methylthio)ethyl!thiourea, useful as a histamine H. sub.2-antagonist.

IMIDAZOLE ALKYLAMINOETHYLENE COMPOUNDS

The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-2-((4-methyl-5-imidazolyl)methylthio)-ethylamino!ethylene.