158863-21-9

Basic information

• Product Name: 6-Benzyloxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole
• CAS NO: 158863-21-9
• Molecular Weight: 353.536
• Mol File: 158863-21-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Benzyloxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Benzyloxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole(158863-21-9)
• EPA Substance Registry System: 6-Benzyloxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole(158863-21-9)

Safety Data

• Hazardous Substances Data: 158863-21-9(Hazardous Substances Data)

Upstream product

• 15903-94-3 6-benzyloxy-1H-indole 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 

Downstream Products

• 57330-46-8 6-(phenylmethoxy)-2-methylindole 
• 158863-22-0 6-(benzyloxy)-2-methyl-1-<<2-(trimethylsilyl)ethoxy>methyl>indole 

Relevant articles and documents

3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a Novel Series of Platelet Activating Factor Antagonists

(2RS,4R)-3-(2-(3-pyridinyl)thiazolidin-4-oyl)indoles represent a new class of potent, orally active antagonists of platelet activating factor (PAF). The compounds were prepared by acylation of the magnesium or zinc salts of substituted indoles with (2RS,4R)-2-(3-pyridinyl)-3-(tert-butoxycarbonyl)thiazolidin-4-oyl chloride. The 3-acylindole moiety functions as a hydrolytically stabilized and conformationally restricted anilide replacement, which imparts a considerable boost in potency to the series. Structure-activity relationships observed for substitution on the indole ring system are discussed. Members of the series compare favorably with other reported PAF antagonists.