158876-69-8

Basic information

• Product Name: Ethanone, 2-(2-chloro-4-pyridinyl)-1-(4-fluorophenyl)-
• Synonyms: 2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)-ethanone;Ethanone,2-(2-chloro-4-pyridinyl)-1-(4-fluorophenyl)
• CAS NO: 158876-69-8
• Molecular Formula: C13H9ClFNO
• Molecular Weight: 249.672
• Mol File: 158876-69-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(2-chloro-4-pyridinyl)-1-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(2-chloro-4-pyridinyl)-1-(4-fluorophenyl)-(158876-69-8)
• EPA Substance Registry System: Ethanone, 2-(2-chloro-4-pyridinyl)-1-(4-fluorophenyl)-(158876-69-8)

Safety Data

• Hazardous Substances Data: 158876-69-8(Hazardous Substances Data)

Upstream product

• 3678-62-4 2-chloro-4-picoline 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 

Downstream Products

• 581098-66-0 4-(4-fluorophenyl)-5-[2-(1-phenylethylamino)pyridin-4-yl]-1,3-dihydro-imidazole-2-thione 
• 581098-41-1 4-(2-chloropyridin-4-yl)-5-(4-fluorophenyl)-1,3-dihydroimidazole-2-thione 
• 581098-29-5 1-(2-chloropyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione 1-oxime 
• 581098-57-9 4-[2-benzylsulfanyl-5-(4-fluorophenyl)-3H-imidazol-4-yl]-2-chloropyridine 
• 581098-43-3 2-chloro-4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridine 

Relevant articles and documents

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of sub