158922-07-7 Usage
Chemical Properties
Light yellow powder with lumps
Check Digit Verification of cas no
The CAS Registry Mumber 158922-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,9,2 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 158922-07:
(8*1)+(7*5)+(6*8)+(5*9)+(4*2)+(3*2)+(2*0)+(1*7)=157
157 % 10 = 7
So 158922-07-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H21NO4/c23-20(24)14-6-5-11-22(12-14)21(25)26-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19H,5-6,11-13H2,(H,23,24)
158922-07-7Relevant articles and documents
Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists
Kulkarni, Santosh S.,Nightingale, Barbara,Dersch, Christina M.,Rothman, Richard B.,Newman, Amy Hauck
, p. 3371 - 3375 (2007/10/03)
A series of diaryl amides was designed and synthesized as novel nonethynyl mGluR5 antagonists. The systematic variation of the pharmacophoric groups led to the identification of a lead compound that demonstrated micromolar affinity for the mGluR5. Further optimization resulted in compounds with improved binding affinities and antagonist profiles, in vitro.
