158940-64-8Relevant articles and documents
Tetrazole-biarylpyrazole derivatives as cannabinoid CB1 receptor antagonists
Kang, Suk Youn,Lee, Sung-Han,Seo, Hee Jeong,Jung, Myung Eun,Ahn, Kwangwoo,Kim, Jeongmin,Lee, Jinhwa
, p. 2385 - 2389 (2008/09/20)
Cannabinoid CB1 receptors have been the focus of extensive studies since the first clinical results of rimonabant (SR141716) for the treatment of obesity and related metabolic disorders were reported in 2001. To further evaluate the properties of CB recep
Potent imidazole and triazole CB1 receptor antagonists related to SR141716
Dyck, Brian,Goodfellow, Val S.,Phillips, Teresa,Grey, Jonathan,Haddach, Mustapha,Rowbottom, Martin,Naeve, Gregory S.,Brown, Brock,Saunders, John
, p. 1151 - 1154 (2007/10/03)
Diarylimidazolecarboxamides and diaryltriazolecarboxamides related to SR141716 were synthesized and tested for binding to the human CB1 receptor. Suitably substituted imidazoles are comparably potent to the clinical candidate, whereas the analo