158942-56-4

Basic information

• Product Name: 5,6-Dimethyl-1,2,3,5-tetrahydro-pyrrolo[2,3-f]indole
• Synonyms: 5,6-Dimethyl-1,2,3,5-tetrahydro-pyrrolo[2,3-f]indole
• CAS NO: 158942-56-4
• Molecular Weight: 186.257
• Mol File: 158942-56-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,6-Dimethyl-1,2,3,5-tetrahydro-pyrrolo[2,3-f]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dimethyl-1,2,3,5-tetrahydro-pyrrolo[2,3-f]indole(158942-56-4)
• EPA Substance Registry System: 5,6-Dimethyl-1,2,3,5-tetrahydro-pyrrolo[2,3-f]indole(158942-56-4)

Safety Data

• Hazardous Substances Data: 158942-56-4(Hazardous Substances Data)

Upstream product

• 4993-96-8 1-(5-aminoindolin-1-yl)ethanone 

Relevant articles and documents

Synthesis, biological activity, and molecular modeling studies of selective 5-HT(2C/2B) receptor antagonists

The synthesis and biological activity are reported for a series of analogues of the previously published indole urea 2 (SB-206553), designed to probe the 5-HT(2C) receptor binding site. Small molecule modeling studies have been used to define a region in space which is allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor. In a complementary approach, docking of 2 into our model of the 5-HT(2C) receptor has allowed us to propose a novel primary binding interaction for this series of diaryl ureas, involving a potential double hydrogen-bonding interaction between the urea carbonyl oxygen of the ligand and two serine residues in the receptor. The difference of two valine residues in the 5-HT(2C) receptor for leucine residues in the 5-HT(2A) receptor is believed to account for the observed 5- HT(2C)/5-HT(2A) selectivity with 2.