158985-00-3 Usage
Description
L-745,870 TRIHYDROCHLORIDE is a compound that serves as a dopamine receptor antagonist, specifically targeting the D4 subtype. It has demonstrated antipsychotic effects in animal models, although its efficacy was not confirmed in human trials.
Uses
Used in Pharmaceutical Industry:
L-745,870 TRIHYDROCHLORIDE is used as a dopamine receptor antagonist for its potential antipsychotic effects. It was initially developed to target the D4 subtype of dopamine receptors, which are believed to be involved in the pathophysiology of certain psychiatric disorders. The compound has shown promise in animal models, but its effectiveness in human trials has not been established.
Used in Research and Development:
In the field of research and development, L-745,870 TRIHYDROCHLORIDE is used as a tool to study the role of dopamine D4 receptors in various physiological and pathological processes. This can help scientists better understand the mechanisms underlying psychiatric disorders and potentially develop more effective treatments in the future.
Biological Activity
A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 158985-00-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,9,8 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 158985-00:
(8*1)+(7*5)+(6*8)+(5*9)+(4*8)+(3*5)+(2*0)+(1*0)=183
183 % 10 = 3
So 158985-00-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H19ClN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H
158985-00-3Relevant articles and documents
3-[[4-(4-Chlorophenyl)piperazin-1-yl]-methyl]-1H-pyrrolo[2,3-b]pyridine: An antagonist with high affinity and selectivity for the human dopamine D4 receptor
Kulagowski, Janusz J.,Broughton, Howard B.,Curtis, Neil R.,Mawer, Ian M.,Ridgill, Mark P.,Baker, Raymond,Emms, Frances,Freedman, Stephen B.,Marwood, Rosemarie,Patel, Shil,Patel, Smita,Ragan, C. Ian,Leeson, Paul D.
, p. 1941 - 1942 (1996)
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Pyrrolo-pyridine derivatives
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, (2008/06/13)
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D 4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia while manifesting fewer side-effects than those associated with classical neuroleptic drugs.
