159000-54-1

Basic information

• Product Name: 2,4-Pyrrolidinedicarboxylicacid,(2R,4S)-rel-(9CI)
• Synonyms: 2,4-Pyrrolidinedicarboxylicacid,(2R,4S)-rel-(9CI)
• CAS NO: 159000-54-1
• Molecular Formula: C6H9NO4
• Molecular Weight: 159.13996
• Product Categories: PYRROLE;CARBOXYLICACID
• Mol File: 159000-54-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 355.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.456±0.06 g/cm3(Predicted)
• PKA: 2.09±0.40(Predicted)
• CAS DataBase Reference: 2,4-Pyrrolidinedicarboxylicacid,(2R,4S)-rel-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrrolidinedicarboxylicacid,(2R,4S)-rel-(9CI)(159000-54-1)
• EPA Substance Registry System: 2,4-Pyrrolidinedicarboxylicacid,(2R,4S)-rel-(9CI)(159000-54-1)

Safety Data

• Hazardous Substances Data: 159000-54-1(Hazardous Substances Data)

Usage

Description

2,4-Pyrrolidinedicarboxylic acid, (2R,4S)-rel-(9CI), is a white crystalline solid with a molecular formula of C7H9NO4. It is a derivative of pyrrolidine, a heterocyclic organic compound. 2,4-Pyrrolidinedicarboxylicacid,(2R,4S)-rel-(9CI) is primarily used in the synthesis of pharmaceuticals and agrochemicals due to its unique (2R,4S) stereochemistry, which is crucial for its specific organic reactions and overall biological activity. Its potential as a chelating agent and a building block in the synthesis of various compounds further expands its applications in the field of organic chemistry and pharmaceutical research.

Uses

Used in Pharmaceutical Industry:
2,4-Pyrrolidinedicarboxylic acid, (2R,4S)-rel-(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique stereochemistry allows for the development of enantiomerically pure drugs, which can exhibit different biological activities and reduce potential side effects.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4-Pyrrolidinedicarboxylic acid, (2R,4S)-rel-(9CI) is utilized in the synthesis of agrochemicals, such as pesticides and herbicides. Its specific stereochemistry enables the development of more effective and targeted agrochemicals with reduced environmental impact.
Used as a Chelating Agent:
2,4-Pyrrolidinedicarboxylic acid, (2R,4S)-rel-(9CI) has been investigated for its potential as a chelating agent. Its ability to form stable complexes with metal ions can be applied in various fields, such as wastewater treatment, where it can help remove heavy metals from industrial effluents.
Used as a Building Block in Organic Synthesis:
2,4-Pyrrolidinedicarboxylicacid,(2R,4S)-rel-(9CI) serves as a versatile building block in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable component in the development of new molecules with potential applications in materials science, pharmaceuticals, and other industries.

Upstream product

• 130830-74-9 N-(benzyloxycarbonyl)-trans-4-carboxy-L-proline 
• 64750-03-4 (2S,4R)-4-methoxycarbonylproline methyl ester 
• 220047-57-4 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine 
• 212266-75-6 (2S,4R)-1-tert-butoxycarbonyl-2-hydroxymethyl-4-hydroxymethylpyrrolidine 
• 212266-76-7 1-(tert-butyl) 2,4-dimethyl (2S,4R)-pyrrolidine-1,2,4-tricarboxylate 
• 212266-74-5 (2R,4R)-3-Benzenesulfonyl-2,4-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 220047-97-2 (2R,3S,4R)-3-Benzenesulfonyl-2,4-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 212266-72-3 ((3R,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol 
• 220047-66-5 ((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol 
• 212266-71-2 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-(S)-1-oxiranylmethyl-amine 
• 212266-69-8 (S)-3-[((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amino]-propane-1,2-diol 
• 212266-68-7 ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine 
• 130930-26-6 N-(benzyloxycarbonyl)-cis-4-hydroxy-L-proline ethyl ester 
• 130830-66-9 N-(benzyloxycarbonyl)-trans-4-cyano-L-proline ethyl ester 

Relevant articles and documents

Selenium-containing photosensitizer as well as preparation method and application thereof

The invention discloses a selenium-containing photosensitizer as well as a preparation method and application thereof. A novel selenium-containing photosensitizer with an anti-tumor angiogenesis effect is synthesized for a first time. The selenium-containing photosensitizer can be applied to treatment on skin scale cancer and is remarkable in effect, the dosage of the selenium-containing photosensitizer is far lower than that of 5-ALA in the market, in addition is free of antibiotics, free of drug resistance and small in side effect, and is safe and non-toxic and economic and practical; in addition, because of the limited light penetration function and other factors, a tumor treatment effect can be achieved even for tumor tissue without light dynamic response through tumor angiogenesis inhibition.

An enantioselective route to pyrrolidines: Removal of the chiral template from homochiral pyrroloimidazoles

Two-step reductive removal of the chiral template from optically active pyrroloimidazoles, available from 1,3-dipolar cycloaddition of homochiral 4,5-dihydroimidazolium ylides, gives optically active substituted pyrrolidines. Selective manipulation of the substituents affords, e.g., naturally occurring and other optically active proline derivatives, and optically active pyrrolizidines and indolizidines.

Asymmetric synthesis of 2,4-disubstituted pyrrolidines

A new strategy for asymmetric synthesis of 2,4-disubstituted pyrrolidines is described, starting from readily available chiral building blocks 1 and (2R)-2,3-O-isopropylideneglycealdehyde (6).