159140-82-6

Basic information

• Product Name: 2,5-bis(4-fluorophenyl)oxazole
• Synonyms: 2,5-bis(4-fluorophenyl)oxazole
• CAS NO: 159140-82-6
• Molecular Weight: 257.239
• Mol File: 159140-82-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,5-bis(4-fluorophenyl)oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis(4-fluorophenyl)oxazole(159140-82-6)
• EPA Substance Registry System: 2,5-bis(4-fluorophenyl)oxazole(159140-82-6)

Safety Data

• Hazardous Substances Data: 159140-82-6(Hazardous Substances Data)

Upstream product

• 288-42-6 oxazol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 128101-19-9 5-(4-fluorophenyl)-1,3-oxazole 

Relevant articles and documents

Orientation effects on C2(5)-C2?(5?) linked bioxazole isomers synthesized via regioselective and sequential C[sbnd]H arylation

Bis(4-fluorophenyl) substituted oxazole (2,5-Oxz) and C2(5)-C2?(5?) linked bioxazole isomers (C2-C2?_BOxz, C2-C5?_BOxz and C5-C5?_BOxz) were concisely synthesized via palladium-catalyzed regioselective and sequential C[sbnd]H arylation in 1–3 reaction steps along with 20%–83% of total yields from oxazole and 4-bromofluorobenzene. The linking orientation plays a key role in the packing geometry and photophysical properties of C2-C2'_BOxz, C2-C5'_BOxz and C5-C5'_BOxz. These bioxazole isomers in solid state showed significant differences in photoluminescence quantum yields (PLQY) (0.33, 0.25 and 0.04, respectively), delayed fluorescence properties and powder X-ray diffraction (PXRD) patterns, suggesting the divergence in intermolecular interactions. The theoretically calculated gradient isosurfaces and complexation energies indicate the existence of intense π-π interactions between molecular layers, which are in good agreement with the variation trend of optical properties.

Iodine catalysed intramolecular C(sp3)-H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp3)-H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.