1591994-64-7

Basic information

• Product Name: ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate
• Synonyms: ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate
• CAS NO: 1591994-64-7
• Molecular Weight: 481.376
• Mol File: 1591994-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate(1591994-64-7)
• EPA Substance Registry System: ethyl 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate(1591994-64-7)

Safety Data

• Hazardous Substances Data: 1591994-64-7(Hazardous Substances Data)

Upstream product

• 1591994-08-9 ethyl 2-(prop-2-ynyloxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate 
• 247092-11-1 2,4-difluoro-benzaldehyde oxime 
• 1021155-28-1 ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1591994-76-1 2-((3-(2,4-difluorophenyl)isoxazole-5-yl)methoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid 

Relevant articles and documents

Synthesis of novel 1,2,3-triazole/isoxazole functionalized 2H-Chromene derivatives and their cytotoxic activity

A series of novel 2-(1,2,3-triazolylmethoxy) 5a-q and isoxazole tagged 6a-g 2H-Chromene derivatives were prepared starting from salicylaldehyde and ethyl-4,4,4-trifluoroacetoacetate via cyclization to form ethyl 2-hydroxy-2-(trifluoromethyl)-2H-Chromene-3-carboxylate 3. Compound 3 on reaction with propargyl bromide resulted compound 4 and was independently reacted with aryl/alkyl azides and aryl aldoximes obtained 2-(1,2,3- triazolylmethoxy) and isoxazole tagged 2H-Chromene derivatives 5a-q, 6a-i, respectively. Compounds 6 were further hydrolysed to acid derivatives 7a-g. All the products 5a-q, 6a-i, 7a-g were screened for cytotoxic activity against four human cancer cell lines and among all the compounds, 5f, 5g, 5l, 5q showed promising activity at 20 μM concentration.