159214-10-5

Basic information

• Product Name: (3-Benzenesulfonylamino-5-methyl-phenoxy)-acetic acid ethyl ester
• CAS NO: 159214-10-5
• Molecular Weight: 349.408
• Mol File: 159214-10-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-Benzenesulfonylamino-5-methyl-phenoxy)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Benzenesulfonylamino-5-methyl-phenoxy)-acetic acid ethyl ester(159214-10-5)
• EPA Substance Registry System: (3-Benzenesulfonylamino-5-methyl-phenoxy)-acetic acid ethyl ester(159214-10-5)

Safety Data

• Hazardous Substances Data: 159214-10-5(Hazardous Substances Data)

Upstream product

• 161291-74-3 2-(3-Hydroxy-5-methyl-phenyl)-isoindole-1,3-dione 
• 76619-89-1 3-amino-5-methylphenol 
• 98-09-9 benzenesulfonyl chloride 
• 159214-15-0 2-(3-amino-5-methyl-phenyloxy)-acetic acid ethyl ester 

Downstream Products

• 176382-23-3 N-[3-(2-aminoethoxy)-5-methyl-phenyl]-benzenesulfonamide 
• 176382-22-2 2-(3-Benzenesulfonylamino-5-methyl-phenoxy)-acetamide 
• 159214-11-6 (3-Benzenesulfonylamino-5-methyl-phenoxy)-acetic acid 

Relevant articles and documents

Diarylsulfonamides as selective, non-peptidic thrombin inhibitors

Based on the structures of aminopyridine thrombin inhibitors (1), a series of aminoalkyl- and guanidinoalkyl-substituted diarylsulfonamides were prepared. The most potent derivative, N-[3-(4-guanidinobutoxy)-5-methyl- phenyl]-benzenesulfonamide (6c) had Ki = 0.18 μM for thrombin and did not inhibit trypsin, plasmin, or factor Xa. Comparison of the X-ray structures of the thrombin / 1b and the thrombin / 6e complexes revealed important aspects which govern the binding of such diarylsulfonamides to thrombin.