15923-61-2

Basic information

• Product Name: (R)-α,α-diphenyl-2-piperidine methanol
• Synonyms: (R)-α,α-diphenyl-2-piperidine methanol
• CAS NO: 15923-61-2
• Molecular Weight: 267.371
• Mol File: 15923-61-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-α,α-diphenyl-2-piperidine methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-α,α-diphenyl-2-piperidine methanol(15923-61-2)
• EPA Substance Registry System: (R)-α,α-diphenyl-2-piperidine methanol(15923-61-2)

Safety Data

• Hazardous Substances Data: 15923-61-2(Hazardous Substances Data)

Upstream product

• 18650-38-9 (R)-piperidine-2-carboxylic acid methyl ester hydrochloride 
• 98-98-6 2-Picolinic acid 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 1016-09-7 benzhydryl methyl ether 

Downstream Products

• 1276058-57-1 (R)-(1-benzylpiperidin-2-yl)diphenylmethanol 

Relevant articles and documents

Addition of the Lithium Anion of Diphenylmethanol Methyl/Methoxymethyl Ether to Nonracemic Sulfinimines: Two-Step Asymmetric Synthesis of Diphenylprolinol Methyl Ether and Chiral (Diphenylmethoxymethyl)amines

Addition of the lithium anion generated from diphenylmethanol methyl and methoxymethyl ether to nonracemic sulfinimines afforded the corresponding addition products in excellent diastereoselctivity and yields. Deprotection of the MOM as well as sulfinyl groups rendered the enantiopure (diphenylhydroxymethyl)amines in excellent yields. The procedure was applied for a two-step synthesis of diphenylprolinol, a privileged ligand in asymmetric catalysis.