15926-18-8 Usage
Description
N-(2-methyl-1-oxopropyl)-glycine, also known as N-isobutyrylglycine, is an N-acylglycine derivative with an isobutyryl acyl group. It is a white solid and is a significant compound in the field of medical diagnostics.
Uses
Used in Medical Diagnostics:
N-(2-methyl-1-oxopropyl)-glycine, or N-isobutyrylglycine, is used as a diagnostic tool for the detection and diagnosis of various organic acidemias and mitochondrial fatty acid β-oxidation defects. Its detection is particularly crucial in identifying isobutyryl-CoA dehydrogenase deficiency, a rare genetic disorder that affects the body's ability to process certain fats and proteins.
In the field of medical diagnostics, N-isobutyrylglycine plays a vital role in identifying and monitoring the progression of these conditions, allowing for early intervention and appropriate treatment plans to be implemented.
Check Digit Verification of cas no
The CAS Registry Mumber 15926-18-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,9,2 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 15926-18:
(7*1)+(6*5)+(5*9)+(4*2)+(3*6)+(2*1)+(1*8)=118
118 % 10 = 8
So 15926-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)
15926-18-8Relevant articles and documents
N-Acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring
Gregersen,Keiding,Kolvraa
, p. 439 - 443 (1979)
Eleven biologically interesting N-acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied. A sharp and reproducible gas chromatographic peak could be obtained for each n-acylglycine as the N,O-bis(trimethylsilyl)-N-acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N-acylglycines in human urine has been developed.
Functionalizing glycine derivatives by direct C-C bond formation
Zhao, Liang,Li, Chao-Jun
supporting information; experimental part, p. 7075 - 7078 (2009/04/07)
(Chemical Equation Presented) Come on glycine: Two different types of glycine derivatives are α-functionalized using cross-dehydrogenative- coupling (CDC) reactions. The method allows the efficient attachment of a malonate or aromatic alkyne group on the α-position of the glycine derivatives under very mild conditions.
Formation of propionyl-, butyryl-, and other acylglycines by enzymes of Clostridium kluyveri.
KATZ,LIEBERMAN,BARKER
, p. 431 - 441 (2007/10/12)
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