159345-08-1

Basic information

• Product Name: (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide
• Synonyms: (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide
• CAS NO: 159345-08-1
• Molecular Weight: 311.424
• Mol File: 159345-08-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide(159345-08-1)
• EPA Substance Registry System: (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide(159345-08-1)

Safety Data

• Hazardous Substances Data: 159345-08-1(Hazardous Substances Data)

Upstream product

• 645-45-4 hydrocinnamic acid chloride 
• 90-82-4 pseudoephedrine 
• 14980-86-0 N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide 
• 74-88-4 methyl iodide 

Downstream Products

• 7384-80-7 (S)-2-methyl-3-phenylpropan-1-ol 
• 5445-77-2 (2S)-2-methyl-3-phenylpropanal 
• 5445-77-2 (2R)-2-methyl-3-phenylpropanal 
• 14367-67-0 2-methyl-3-phenylpropionic acid 
• 1009-67-2 2-methyl-3-phenylpropionic acid 

Relevant articles and documents

Pseudoephedrine as a practical chiral auxiliary for the synthesis of highly enantiomerically enriched carboxylic acids, alcohols, aldehydes, and ketones

The use of pseudoephedrine as a practical chiral auxiliary for asymmetric synthesis is described in full. Both enantiomers of pseudoephedrine are inexpensive commodity chemicals and can be N-acylated in high yields to form tertiary amides. In the presence of lithium chloride, the enolates of the corresponding pseudoephedrine amides undergo highly diastereoselective alkylations with a wide range of alkyl halides to afford α-substituted products in high yields. These products can then be transformed in a single operation into highly enantiomerically enriched carboxylic acids, alcohols, aldehydes, and ketones.