1593735-39-7Relevant articles and documents
INDOLO[3, 2-C]QUINOLINE DERIVATIVE, METHOD FOR PRODUCING THE DERIVATIVE, AND ANTIMALARIAL AGENT AND ANTICANCER AGENT COMPRISING THE DERIVATIVE
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Paragraph 0139; 0140; 0152, (2016/10/10)
PROBLEM TO BE SOLVED: To provide an antimalarial agent having high antimalarial activity (especially, effective even against chloroquine-resistant malaria parasites) and high safety, and an anticancer agent having high antitumor activity and low toxicity for non-tumor cells. SOLUTION: Provided are an antimalarial agent and an anticancer agent comprising an indolo [3,2-c] quinoline derivative (A) represented by the following formula (A) or a pharmaceutically acceptable salt thereof as an active ingredient. In the formula (A), R1 represents a prescribed substituent such as a halogen atom or the like; R2 represents a prescribed substituent such as an aminoalkylamino group or the like; R3 represents an alkyl group; R4 represents a prescribed substituent such as a halogen atom or the like; n represents an integer of 1 to 4; and m represents an integer of 0 to 4. COPYRIGHT: (C)2015,JPO&INPIT
Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11
Wang, Ning,Wicht, Kathryn J.,Imai, Kento,Wang, Ming-Qi,Anh Ngoc, Tran,Kiguchi, Ryo,Kaiser, Marcel,Egan, Timothy J.,Inokuchi, Tsutomu
, p. 2629 - 2642 (2014/05/06)
A series of indolo[3,2-c]quinolines were synthesized by modifying the side chains of the ω-aminoalkylamines at the C6 position and introducing substituents at the C2 position, such as F, Cl, Br, Me, MeO and NO2, and a methyl group at the N11 po
