159383-84-3

Basic information

• Product Name: 1,2-Propanediol, 3,3,3-trifluoro-2-phenyl-, (2R)-
• CAS NO: 159383-84-3
• Molecular Formula: C9H9F3O2
• Molecular Weight: 206.164
• Mol File: 159383-84-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Propanediol, 3,3,3-trifluoro-2-phenyl-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanediol, 3,3,3-trifluoro-2-phenyl-, (2R)-(159383-84-3)
• EPA Substance Registry System: 1,2-Propanediol, 3,3,3-trifluoro-2-phenyl-, (2R)-(159383-84-3)

Safety Data

• Hazardous Substances Data: 159383-84-3(Hazardous Substances Data)

Upstream product

• 384-64-5 3,3,3-trifluoro-2-phenylpropene 
• 1070872-70-6 (2R)-2-allyloxy-3,3,3-trifluoro-2-phenyl-propan-1-ol 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 17257-70-4 (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid 
• 537695-75-3 (R)-3-(tert-butyldimethylsilyloxy)-1,1,1-trifluoro-2-phenylpropan-2-ol 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 537695-87-7 (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanol 
• 537695-82-2 (R)-3-(tert-butyldimethylsilyloxy)-1,1,1-trifluoro-2-methoxy-2-phenylpropane 

Relevant articles and documents

A short route to a Mosher's acid precursor via catalytic asymmetric dihydroxylation (AD)

α-Methoxy-α-(trifluoromethyl)phenyl acetic acid (MTPA) is a valuable derivatizing agent for enantiomeric excess determination of alcohols and amines. A short synthesis of a precursor to this compound, based on the asymmetric dihydroxylation (AD) reaction

Enantioselective synthesis of arylmethoxyacetic acid derivatives

The preparation of several arylmethoxyacetic acids by a sequence of asymmetric dihydroxylation and further oxidation of the resulting glycol with TEMPO/NaClO/NaClO2 is described. The scope and limitations of the reaction are discussed.