159386-48-8Relevant articles and documents
Preparation method of arylalkyl phosphorus oxide compounds
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Paragraph 0044; 0045; 0046, (2019/04/09)
A preparation method of arylalkyl phosphorus oxide compounds is provided. The invention discloses a preparation method of several arylalkyl phosphorus oxide compounds. The preparation method includes:taking diphenylphosphine oxyhydrogen of 1.3 equivalent, 2.5% by mass nickel catalyst (with or without ligands) or palladium catalyst with ligands and a base of 1.5 equivalent from a glovebox, addingthem sequentially into a Schlenk reaction tube, adding a nitrile compound of 1.0 equivalent, vacuumizing, and backfilling with nitrogen; in the nitrogen atmosphere, adding a solvent, and allowing reaction to occur continuously at 120 DEG C for 16 h; after reaction, cooling to room temperature, and performing column chromatography separation to obtain the target product under high selectivity and high yield. The preparation method herein allows sp3C-CN\P-H cross coupling; reaction conditions are mild; operating is easy; the preparation process is simple; the target product has high conversion rate and high yield; the problems of other synthetic methods are solved that, for instance, two-step reaction system is complex, many organic and inorganic byproducts are produced, environmental pollution is caused easily, and the substrate range is narrow; the preparation method has a good industrial application prospect.
The synthesis of (E) and (Z)-combretastatins A-4 and a phenanthrene from Combretum caffrum
Lawrence, Nicholas J.,Ghani, Fazni Abdul,Hepworth, Lucy A.,Hadfield, John A.,McGown, Alan T.,Pritchard, Robin G.
, p. 1656 - 1660 (2007/10/03)
The synthesis of the trans stilbene E-combretastatin A-4 has been achieved via a Horner-Wittig reaction of (3,4,5- trimethoxybenzyl)diphenylphosphine oxide. The anticancer drug Z- combretastatin A-4 was prepared by the hydroboration/protonation of a diaryl- alkyne.
