1593954-10-9

Basic information

• Product Name: C₁₉H₁₆FN₇O
• CAS NO: 1593954-10-9
• Molecular Weight: 377.381
• Mol File: 1593954-10-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₆FN₇O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₆FN₇O(1593954-10-9)
• EPA Substance Registry System: C₁₉H₁₆FN₇O(1593954-10-9)

Safety Data

• Hazardous Substances Data: 1593954-10-9(Hazardous Substances Data)

Upstream product

• 4752-10-7 1,4-dichlorophthalazine 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 52494-54-9 6-chloro-tetrazolo[5,1-a]-phthalazine 
• 102391-98-0 1-(4-fluorobenzoyl)piperazine 
• 51935-42-3 1-chloro-4-hydrazinophthalazine 
• 85-44-9 phthalic anhydride 

Relevant articles and documents

Synthesis and positive inotropic evaluation of [1,2,4]triazolo[3,4-a] phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties

Four series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a] phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume in isolated rabbit-heart preparations. Several compounds were developed and showed favorable activities compared to the standard drug milrinone, with (4-([1,2,4]triazolo[3,4-a]phthalazin-6-yl)piperazin-1-yl)(p- tolyl)methanone (5g) being identified as the most potent with an increased stroke volume of 19.15 ± 0.22% (milrinone: 2.46 ± 0.07%) at a concentration of 3 × 10-5 M. A preliminary study of mechanism of action revealed that 5g displayed its positive inotropic effect may be related to the PDE-cAMP-PKA signaling pathway. Compounds exhibiting inotropic effects were also evaluated in terms of the chronotropic effects.