1594094-64-0

Basic information

• Product Name: CW069
• Synonyms: CW069;5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]benzoic acid;Benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-
• CAS NO: 1594094-64-0
• Molecular Formula: C23H21IN2O3
• Molecular Weight: 500.32891
• Product Categories: Inhibitors
• Mol File: 1594094-64-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 666.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.559±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: ≥50 mg/mL in DMSO; insoluble in H2O; ≥51.6 mg/mL in EtOH
• PKA: 2.69±0.10(Predicted)
• CAS DataBase Reference: CW069(CAS DataBase Reference)
• NIST Chemistry Reference: CW069(1594094-64-0)
• EPA Substance Registry System: CW069(1594094-64-0)

Safety Data

• Hazardous Substances Data: 1594094-64-0(Hazardous Substances Data)

Usage

Description

CW069 is an allosteric inhibitor of KIFC/HSET, a microtubule motor protein that plays a crucial role in bipolar spindle assembly and centrosome clustering. It is characterized by its ability to increase the number of multipolar spindles in cells with supernumerary centrosomes, specifically in N1E-115 mouse neuroblastoma cells. Notably, CW069 does not affect the morphology of mitotic spindles in normal human dermal fibroblast (NHDF) cells and selectively inhibits the proliferation of N1E-115 cells.

Uses

Used in Cellular Research:
CW069 is used as a research tool for studying the role of KIFC/HSET in cellular processes, particularly in the context of bipolar spindle assembly and centrosome clustering. Its ability to induce multipolar mitoses in cells with supernumerary centrosomes makes it a valuable compound for investigating the underlying mechanisms and potential therapeutic targets in various diseases.
Used in Anticancer Applications:
CW069 is used as an allosteric inhibitor of the microtubule motor protein HSET for its potential anticancer properties. By inducing multipolar mitoses specifically in cells containing supernumerary centrosomes, CW069 may offer a targeted approach to disrupting cancer cell division and proliferation, thereby exhibiting potential therapeutic benefits in cancer treatment.
Used in Drug Development:
CW069 serves as a starting point for the development of novel therapeutics that target KIFC/HSET and related cellular processes. Its selective inhibition of cancer cell proliferation, without affecting normal cell mitotic spindle morphology, highlights its potential in the development of more effective and less toxic cancer treatments.

references

[1]. watts ca, richards fm, bender a, et al. design, synthesis, and biological evaluation of an allosteric inhibitor of hset that targets cancer cells with supernumerary centrosomes. chem biol, 2013, 20(11): 1399-1410.