15958-92-6 Usage
Description
ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE, also known as [Des-Arg9]-Bradykinin, is an eight-membered oligopeptide composed of Arg, Pro, Pro, Gly, Phe, Ser, Pro, and Phe residues joined in sequence. It is an analogue of bradykinin that lacks the Arg residue at position 9. This modification results in a highly potent antagonist at B1 receptors, making it a valuable compound for pharmaceutical research and development.
Uses
Used in Pharmaceutical Research:
ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE is used as a research compound for studying new bradykinin antagonists with very high potency at B1 receptors. The compound's unique structure and properties make it a promising candidate for the development of novel therapeutic agents targeting the bradykinin system, which is involved in various physiological processes, including pain, inflammation, and blood pressure regulation.
Used in Drug Development:
In the pharmaceutical industry, ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE is used as a lead compound for the development of new drugs targeting B1 receptors. Its high potency and selectivity make it an attractive starting point for designing and optimizing novel therapeutic agents with potential applications in treating various conditions related to the bradykinin system, such as pain, inflammation, and cardiovascular diseases.
Used in Diagnostic Applications:
In the medical industry, ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE can be used as a diagnostic tool for assessing the functionality of B1 receptors in patients. By measuring the binding affinity and potency of this compound at B1 receptors, researchers and clinicians can gain valuable insights into the receptor's role in disease progression and potential therapeutic interventions.
Used in Academic Research:
In the field of academic research, ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE serves as an important tool for studying the molecular mechanisms underlying the actions of bradykinin and its receptors. This knowledge can contribute to a better understanding of the complex signaling pathways involved in various physiological and pathological processes, ultimately leading to the development of more effective and targeted therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 15958-92-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,9,5 and 8 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15958-92:
(7*1)+(6*5)+(5*9)+(4*5)+(3*8)+(2*9)+(1*2)=146
146 % 10 = 6
So 15958-92-6 is a valid CAS Registry Number.
InChI:InChI=1/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)/t29-,30-,31-,32-,33-,34-,35-/m0/s1
15958-92-6Relevant articles and documents
ACTION ON PEPTIDES BY WHEAT CARBOXYPEPTIDASE
Umetsu, H.,Ichishima, E.
, p. 591 - 592 (2007/10/02)
A kinetic analysis has been performed with purified wheat carboxypeptidase by the use of N-acyl dipeptides, Z-Gly-Pro-Leu-Gly (Z=benzyloxycarbonyl), angiotensin II and bradykinin.The values of kcat were dramatically influenced by amino acid residues occupying the penultimate position from the carbonyl terminus of substrates.The structure of the substrate did not appreciably affect the Km values. Key Word Index - Triticum aestivum; Gramineae; wheat; carboxypeptidase; peptides; kinetic parameters.
