1596118-87-4

Basic information

• Product Name: 4-acetyl-1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazole
• Synonyms: 4-acetyl-1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazole
• CAS NO: 1596118-87-4
• Molecular Weight: 251.236
• Mol File: 1596118-87-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-acetyl-1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetyl-1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazole(1596118-87-4)
• EPA Substance Registry System: 4-acetyl-1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazole(1596118-87-4)

Safety Data

• Hazardous Substances Data: 1596118-87-4(Hazardous Substances Data)

Upstream product

• 106308-60-5 2-(azidomethyl)-1,3-difluorobenzene 
• 123-54-6 acetylacetone 

Downstream Products

• 1596118-88-5 2-(1-(2,6-difluorobenzyl)-5-methyl-1H-1,2,3-triazolo-4-yl)pent-4-en-2-ol 

Relevant articles and documents

Organoallylaluminum reagents promote easy access to trihalomethyl triazolyl homoallylic alcohols analogous to rufinamide

The results of allylation reactions employing allylaluminum reagents are described for 5-substituted (2,6-difluorobenzyl)-4-trifluoro(chloro)acetyl-1H-1, 2,3-triazoles (1), in which the 5-substituents are H, Me, and Ph. The allylating reagents were generated in situ by the catalytic insertion of aluminum into allyl and crotyl bromides (2), in order to furnish a new series of twelve trihalomethyl triazolyl homoallylic alcohols (3) at yields of up to 94%. The excellent reactivity of these organoallyl reagents is highlighted as an economical alternative to the indium-mediated reactions to produce homoallylic alcohols, which are important building blocks in organic synthesis.