159634-93-2Relevant articles and documents
Tripeptide growth hormone secretagogues
Yang, Lihu,Morriello, Greg,Pan, Yanping,Nargund, Ravi P.,Barakat, Khaled,Prendergast, Kristine,Cheng, Kang,Chan, Wanda W.-S.,Smith, Roy G.,Patchett, Arthur A.
, p. 759 - 764 (2007/10/03)
A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) sccretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa- hepta-GH releasing peptides can be mimicked at the tripeptide level.