159689-88-0 Usage
Description
3-(Trifluoromethoxy)benzyl bromide is a colorless liquid that is utilized in various chemical reactions and synthesis processes due to its unique chemical properties. It is known for its reactivity in the Friedel-Crafts polymerization when catalyzed by aluminum chloride, which allows for the formation of specific polymers.
Uses
Used in Pharmaceutical Industry:
3-(Trifluoromethoxy)benzyl bromide is used as a reagent for the preparation of aminophosphorylalkanoic acid derivatives, which serve as inhibitors of aminopeptidase A. These inhibitors play a crucial role in the development of medications targeting various diseases and conditions, particularly those related to enzyme activity.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-(Trifluoromethoxy)benzyl bromide is employed as a key intermediate in the creation of various organic compounds. Its unique structure and reactivity make it a valuable component in the synthesis of complex molecules for a wide range of applications, including pharmaceuticals, agrochemicals, and materials science.
Used in Polymer Science:
3-(Trifluoromethoxy)benzyl bromide is used as a monomer in the Friedel-Crafts polymerization process, facilitated by an aluminum chloride catalyst. This reaction allows for the production of polymers with specific properties, which can be tailored for use in various industries such as plastics, coatings, and adhesives.
Check Digit Verification of cas no
The CAS Registry Mumber 159689-88-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,6,8 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 159689-88:
(8*1)+(7*5)+(6*9)+(5*6)+(4*8)+(3*9)+(2*8)+(1*8)=210
210 % 10 = 0
So 159689-88-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H4BrF3O2/c9-7(13)5-2-1-3-6(4-5)14-8(10,11)12/h1-4H/p+1
159689-88-0Relevant articles and documents
Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids
Tan, Xinqiang,Song, Tao,Wang, Zhentao,Chen, He,Cui, Lei,Li, Chaozhong
, p. 1634 - 1637 (2017)
The silver-catalyzed Hunsdiecker bromination of aliphatic carboxylic acids is described. With Ag(Phen)2OTf as the catalyst and dibromoisocyanuric acid as the brominating agent, various aliphatic carboxylic acids underwent decarboxylative bromination to provide the corresponding alkyl bromides under mild conditions. This method not only is efficient and general but also enjoys wide functional group compatibility. An oxidative radical mechanism involving Ag(II) intermediates is proposed.
