159707-06-9

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, [3,5-bis(trifluoromethyl)phenyl]methyl ester
• CAS NO: 159707-06-9
• Molecular Formula: C10H5F9O3S
• Molecular Weight: 376.2
• Mol File: 159707-06-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, [3,5-bis(trifluoromethyl)phenyl]methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, [3,5-bis(trifluoromethyl)phenyl]methyl ester(159707-06-9)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, [3,5-bis(trifluoromethyl)phenyl]methyl ester(159707-06-9)

Safety Data

• Hazardous Substances Data: 159707-06-9(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 32707-89-4 3,5-bis(trifluoromethyl)benzenemethanol 
• 38222-83-2 2,6-di-tert-butyl-4-methylpyridine 

Downstream Products

• 159813-00-0 (2S,3S)-2-((3,5-bis(trifluoromethyl)benzyl)oxy)-3-phenylmorpholine 
• 159706-37-3 (2R,3S)-4-Benzyl-2-(3,5-bis-trifluoromethyl-benzyloxy)-3-phenyl-morpholine 
• 159706-36-2 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)-phenylmorpholine 

Relevant articles and documents

MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS

Substituted heterocycles of the general structural formula: STR1 are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.

Stereoselective synthesis of 2-(S)-(3,5-bis(trifluoromethyl) benzyloxy)-3-(S)-phenyl-1,4-oxazine

A convenient process for the preparation of the secondary amine 6, 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)- (3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-1,4-oxazine, is described starting from the readily available (S)-phenylglycine 1. The process features efficient construction of the homochiral oxazinone intermediate 3 and stereoselective introduction of the 2-(3,5-bis(trifluoromethyl)-benzyloxy) group by L-Selectride reduction followed by in situ alkylation with the highly reactive 3,5-bis(trifluoromethyl)-benzyl triflate 4.