159857-60-0

Basic information

• Product Name: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine
• Synonyms: (S)-2-(((9H-fluoren-9-yl)methyl9H-fluoren-9-yl)methoxy)carbonylamino)-6-((4-methoxyphenyl)diphenylmethylamino)hexanoic acid;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-[(4-methoxyphenyl)diphenylmethyl]-L-lysine;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexan;N6-(4-Methoxytrityl)-L-lysine, N2-FMOC protected;N6-[Diphenyl(4-methoxyphenyl)methyl]-N2-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-lysine, FMOC-L-LYS(MMT)-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)he;Nα-Fmoc-Nε-4-methoxyyltrityl-L-lysine≥ 99.8% (HPLC, Chiral purity)
• CAS NO: 159857-60-0
• Molecular Formula: C₄₁H₄₀N₂O₅
• Molecular Weight: 640.7667
• Product Categories: amino acids
• Mol File: 159857-60-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 814.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.210
• Storage Temp.: Store at +2°C to +8°C.
• PKA: 3.83±0.21(Predicted)
• CAS DataBase Reference: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine(CAS DataBase Reference)
• NIST Chemistry Reference: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine(159857-60-0)
• EPA Substance Registry System: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine(159857-60-0)

Safety Data

• Hazardous Substances Data: 159857-60-0(Hazardous Substances Data)

Usage

Description

N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine is a specialized chemical compound used in the field of peptide synthesis. It is an excellent derivative for the synthesis of branched peptides and peptides modified at the lysine side-chain, as well as for the construction of templates and multifunctionalized resins for combinatorial synthesis. The compound is characterized by its white to pale brown solid appearance.

Uses

Used in Pharmaceutical Industry:
N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine is used as a building block for the synthesis of complex peptides and proteins. Its application is crucial in the development of new drugs and therapies, particularly in the areas of cancer treatment and other diseases.
Used in Research and Development:
In the research and development sector, N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine is utilized for the creation of novel peptide-based compounds with potential applications in various fields, including medicine, agriculture, and biotechnology.
Used in Combinatorial Synthesis:
N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine is employed as a key component in the construction of templates and multifunctionalized resins for combinatorial synthesis. This technique allows for the rapid generation of a large number of peptide variants, which can be screened for specific biological activities or properties.
Used in Peptide Synthesis Methodologies:
The compound is used as a reagent in various peptide synthesis methodologies, such as solid-phase peptide synthesis (SPPS) and liquid-phase peptide synthesis (LPPS), to facilitate the formation of peptide bonds and improve the overall efficiency of the process.
Used in the Removal of Protecting Groups:
N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine is used in the selective removal of the side-chain Mmt group, which can be achieved using different conditions, such as 1% TFA in DCM or milder conditions with AcOH/TFE/DCM. This selective removal is essential for the synthesis of branched peptides and peptides with modified lysine side-chains.

Upstream product

• 105047-45-8 Fmoc-Lys-OH 
• 14470-28-1 mono-4-methoxytrityl chloride 

Downstream Products

• 159857-61-1 (S)-2-amino-6-((4-methoxyphenyl)diphenylmethyl-amino)hexanoic acid 
• 450366-22-0 Fmoc-Lys(Mmt)-aminobenzyl alcohol 
• 439286-56-3 (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide 
• 159857-64-4 (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide 
• 159857-65-5 MC-Phe-Lys(MMT)-PAB-OH 
• 159857-63-3 Fmoc-Phe-Lys(MMT)-PABOH 
• 159857-62-2 Fmoc-Phe-Lys(MMT) 
• 159857-66-6 Carbonic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-phenyl-propionylamino}-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-benzyl ester 4-nitro-phenyl ester 

Relevant articles and documents

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