159870-86-7

Basic information

• Product Name: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZOTHIAZOLE
• Synonyms: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZOTHIAZOLE;2-chloro-6-(trifluoromethyl)benzo[d]thiazole;2-chloro-6-(trifluoroMethyl)-1,3-benzothiazole;Benzothiazole, 2-chloro-6-(trifluoroMethyl)-
• CAS NO: 159870-86-7
• Molecular Formula: C₈H₃ClF₃NS
• Molecular Weight: 237.63
• Mol File: 159870-86-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 258℃
• Flash Point: 110℃
• Appearance: pale yellow brown powder
• Density: 1.566
• Vapor Pressure: 0.023mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.65±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZOTHIAZOLE(159870-86-7)
• EPA Substance Registry System: 2-CHLORO-6-(TRIFLUOROMETHYL)BENZOTHIAZOLE(159870-86-7)

Safety Data

• Hazardous Substances Data: 159870-86-7(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

2-Chloro-6-trifluoromethylbenzothiazole

InChI:InChI=1/C8H3ClF3NS/c9-7-13-5-2-1-4(8(10,11)12)3-6(5)14-7/h1-3H

Upstream product

• 401567-22-4 6-trifluoromethyl-1,3-benzothiazole-2-thiol 
• 39885-50-2 2-chloro-4-(trifluoromethyl)aniline 
• 777-12-8 2-amino-6-trifluoromethyl-1,3-benzothiazole 

Relevant articles and documents

NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.

A convenient synthesis of 2-mercapto and 2-chlorobenzothiazoles

A convenient synthesis of 2-mercapto and 2-chlorobenzothiazoles is described. The key feature of the synthesis is an exclusive ortho-selective nucleophilic aromatic substitution reaction of ortho-haloanilines with potassium/sodium O-ethyl dithiocarbonate under mild conditions. Subsequent intra-molecular cyclization affords 2-mercaptobenzothiazoles in high yields. The 2-mercaptobenzothiazoles are readily converted to corresponding 2-chlorobenzothiazoles upon treatment with sulfuryl chloride.