159877-36-8

Basic information

• Product Name: 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE
• Synonyms: 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE;tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate;Octahydro-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester
• CAS NO: 159877-36-8
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.32
• Product Categories: pharmacetical;Heterocycle-Pyridine series
• Mol File: 159877-36-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 313.81 °C at 760 mmHg
• Flash Point: 143.587 °C
• Appearance: /
• Density: 1.053 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: 2-8°C
• PKA: 10.66±0.20(Predicted)
• CAS DataBase Reference: 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE(159877-36-8)
• EPA Substance Registry System: 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE(159877-36-8)

Safety Data

• Hazardous Substances Data: 159877-36-8(Hazardous Substances Data)

Usage

General Description

1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE is a chemical compound that is commonly used in the pharmaceutical industry for the synthesis of various drugs. It is a bicyclic heterocyclic compound with a BOC (tert-butyloxycarbonyl) protecting group attached to the nitrogen atom. 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE is known for its ability to act as a versatile intermediate in the synthesis of various heterocyclic compounds with potential therapeutic activities. Its unique structure and reactivity make it a valuable building block in the creation of new drug candidates and pharmaceuticals. Additionally, this compound can also serve as a valuable tool in the study of chemical reactions and organic synthesis.

InChI:InChI=1/C12H22N2O2/c1-12(2,3)16-11(15)14-6-4-5-9-7-13-8-10(9)14/h9-10,13H,4-8H2,1-3H3

Upstream product

• 868136-22-5 (4aR,7aR)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate 
• 159877-35-7 tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate 
• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 128740-14-7 (R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]-nonane 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 

Downstream Products

• 1059609-03-8 8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-ylcarbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide 
• 1438082-56-4 tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[3,4-b] pyridine-1-carboxylate 
• 1438073-26-7 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1443216-54-3 C₃₁H₄₀N₆O₅ 
• 1443216-76-9 C₂₆H₃₂N₆O₃ 

Relevant articles and documents

Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment

A series of octahydropyrrolo[3,4-c]pyrroles were synthesized and evaluated by orexin 1 and 2 receptor (OX1 & 2R) antagonists assays. Compound 14l with potent OXR antagonist activity and suitable pharmacokinetic behavior was chosen to be investigated in an EEG study, which demonstrated effects of sleep promotion comparable to Suvorexant. Furthermore, the di-fluro substituted analogs exhibited reduced hERG inhibition while maintaining moderate potency.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

FURO[3,2-D]PYRIMIDINE DERIVATIVES

Furo[3,2-d]pyrimidine derivatives of formula I, wherein the meanings for the various substituents are as defined in the description. These compounds are useful as H4 receptor antagonists.