1599466-81-5 Usage
Description
XPhos Palladacycle Gen. 4 is a powerful ligand used in cross-coupling reactions, specifically when combined with the Buchwald Fourth Generation Palladacycle. It is bench stable and soluble in most organic solvents, making it a versatile and efficient catalyst for various chemical reactions.
Uses
Used in Chemical Synthesis:
XPhos Palladacycle Gen. 4 is used as a catalyst in cross-coupling reactions for the formation of carbon-carbon and carbon-heteroatom bonds. Its application reason is to facilitate the formation of complex molecular structures with high efficiency and selectivity.
Used in Pharmaceutical Industry:
XPhos Palladacycle Gen. 4 is used as a catalyst in the synthesis of complex pharmaceutical compounds. Its application reason is to enable the production of novel drug candidates with improved potency, selectivity, and reduced side effects.
Used in Material Science:
XPhos Palladacycle Gen. 4 is used as a catalyst in the development of advanced materials, such as polymers and nanoparticles. Its application reason is to promote the synthesis of materials with tailored properties for various applications, including electronics, energy storage, and environmental remediation.
Used in Agrochemical Industry:
XPhos Palladacycle Gen. 4 is used as a catalyst in the synthesis of agrochemicals, such as pesticides and herbicides. Its application reason is to enable the development of more effective and environmentally friendly products for agricultural use.
Reactions
Palladium catalyst used in the Suzuki-Miyaura coupling of unstable boronic acids.
Check Digit Verification of cas no
The CAS Registry Mumber 1599466-81-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,9,9,4,6 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1599466-81:
(9*1)+(8*5)+(7*9)+(6*9)+(5*4)+(4*6)+(3*6)+(2*8)+(1*1)=245
245 % 10 = 5
So 1599466-81-5 is a valid CAS Registry Number.
1599466-81-5Relevant articles and documents
N-substituted 2-aminobiphenylpalladium methanesulfonate precatalysts and their use in C-C and C-N cross-couplings
Bruno, Nicholas C.,Niljianskul, Nootaree,Buchwald, Stephen L.
, p. 4161 - 4166 (2014/05/20)
A series of phosphine-ligated palladium precatalysts based on N-methyl- and N-phenyl-2-aminobiphenyl have been developed. Substitution at the nitrogen center prevents the presence of traces of aminobiphenyls that contain a free -NH2 group from contaminating cross-coupling products. These precatalysts produce N-substituted carbazoles upon activation, which cannot consume starting materials. These precatalysts were efficiently generated from 2-aminobiphenyl with minimal purification and found to be highly effective in Suzuki-Miyaura and C-N cross-coupling reactions.
