15998-93-3Relevant articles and documents
A method for synthesizing graciousness mixed lu an
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Paragraph 0041-0043, (2017/09/12)
The invention discloses a novel method for compounding enzalutamide, belongs to the technical field of pharmacy synthetic technology, and particularly relates to novel technology for compounding enzalutamide. Most known methods for compounding enzalutamide relate to use of highly toxic and mephitical thiophosgene and highly toxic oxobutyronitrile, and have relatively great difficulty for industrialization. According to the invention, non-toxic and harmless thiourea and an isobutyric acid derivative are used for a reaction to obtain a key parent nucleus of 5,5-dimethyl-2-thioketone imidazole-4-ketone, and therefore, thiophosgene and oxobutyronitrile are effectively avoided. The method has a mild reaction condition, is relatively high in yield, and therefore has a great industrial prospect.
Reaction of Trimethylsilyl Isocyanate and Isothiocyanate with 3-(Dialkylamino)-2H-azirines. A Facile Synthesis of 1-Unsubstituted 4-(Dialkylamino)imidazolin-2-ones and 4-(Dialkylamino)imidazoline-2-thiones
Handke, Isabel,Schaumann, Ernst
, p. 5298 - 5300 (2007/10/02)
The reaction of azirines 3a,b,d,e with trimethylsilyl isocyanate (4) or isothiocyanate (5) gives imidazolinones 6a,b,e and thiones 7a,b,d,e, respectively.However, in an alternate reaction course, azirine 3c leads to amidinium salts 9.The potential of the
Soil disease-controlling imides
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, (2008/06/13)
A soil disease controlling agent for preventing and controlling diseases caused by pathogenic fungi living in soil, which comprises an effective amount of at least one of a 2-cycloalkenylamine derivative and its salts as an active ingredient, and at least one inert carrier or diluent.