160056-33-7Relevant articles and documents
Synthesis and resolution of dinucleotide(TpAZT) phosphoramidates
Lin, Changxue,Fu, Hua,Tu, Guangzhong,Zhao, Yufen
, p. 2553 - 2562 (2007/10/03)
Dinucleotide (TpAZT) phosphoramidates were synthesized through Atherton-Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Spu) were separated by crystallization. It was showed that the cheap methyl esters of natural alanine and phenylalanine could act as new chiral auxiliaries for large-scale synthesis of dinucleotide analogs.
31p NMR studies on oxidative transformations of aryl nucleoside h-phosphonate diesters
Kers, Annika,Kers, Inger,Cieslak, Jacek,Kraszewski, Adam,Stawinski, Jacek
, p. 991 - 992 (2007/10/03)
Various aspects of oxidative coupling of nucleoside aryl H-phosphonate diesters with nucleosides to produce important synthetic intermediates in the phosphotriester approach to oligonucleotide synthesis, dinucleoside aryl phosphotriesters, was investigated. Copyright
Aryl H-phosphonates. 8. Simple and efficient method for the preparation of nucleoside B-phosphonothioate monoesters
Kers, Inger,Kers, Annika,Stawinski, Jacek,Kraszewski, Adam
, p. 3945 - 3948 (2007/10/03)
An efficient method for the preparation of nucleoside 3'-H- phosphonothioate monoesters was developed. It consists of phosphonylation of suitably protected nucleosides with diphenyl H-phosphonate to produce nucleoside phenyl H-phosphonates, followed by th