160087-98-9

Basic information

• Product Name: 4-Keto Ibutilide
• Synonyms: 4-Keto Ibutilide;(±)-N-Ethyl-N-heptyl-γ-hydroxy-4-[(Methylsulfonyl)aMino]benzenebutanaMide;N-Ethyl-N-heptyl-γ-hydroxy-4-[(Methylsulfonyl)aMino]benzenebutanaMide;Ibutilide Related CoMpound B
• CAS NO: 160087-98-9
• Molecular Formula: C20H34N2O4S
• Molecular Weight: 398.55996
• Product Categories: Amines;Aromatics;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 160087-98-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Keto Ibutilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Keto Ibutilide(160087-98-9)
• EPA Substance Registry System: 4-Keto Ibutilide(160087-98-9)

Safety Data

• Hazardous Substances Data: 160087-98-9(Hazardous Substances Data)

Upstream product

• 100632-58-4 N-<4-<4-(ethyl-n-heptylamino)-1,4-dioxo-butyl>phenyl>methanesulfonamide 

Relevant articles and documents

Synthesis of (R)-N-[4-[4-(dibutylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (artilide fumarate) and the enantiomers of N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate)

Syntheses of artilide fumarate, its (S) enantiomer and the (R) and (S) enantiomers of ibutilide fumarate were achieved by reduction of the prochiral ketones with (+) and (-)-B-chlorodiisopinocampheylborane. Several methods for analyzing the optical purity of these compounds are presented. The absolute configurations were established by a single crystal X-ray crystallographic analysis of (S)-N-[4-[4-(dibutylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide. Copyright