160089-27-0

Basic information

• Product Name: 1-phenylamino-3-ethyl-3-methylpyrrolidine-2,5-dione
• CAS NO: 160089-27-0
• Molecular Weight: 232.282
• Mol File: 160089-27-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-phenylamino-3-ethyl-3-methylpyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylamino-3-ethyl-3-methylpyrrolidine-2,5-dione(160089-27-0)
• EPA Substance Registry System: 1-phenylamino-3-ethyl-3-methylpyrrolidine-2,5-dione(160089-27-0)

Safety Data

• Hazardous Substances Data: 160089-27-0(Hazardous Substances Data)

Upstream product

• 631-31-2 2-ethyl-2-methylsuccinic acid 
• 100-63-0 phenylhydrazine 

Relevant articles and documents

Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones

In the present study on the development of new anticonvulsants, the library of differently substituted N-phenylamino pyrrolidine-2,5-dione and hexahydro-isoindole-1,3-dione derivatives was synthesized. The anticonvulsant activity of all the compounds was evaluated using the maximal electroshock (MES) and pentylenetetrazole (scPTZ) screens, which are the most widely employed seizure models for early identification of candidate anticonvulsants. Their neurotoxicity was determined applying the rotorod test. The pharmacological results revealed that the majority of compounds were effective in electrical (MES) and/or pentylenetetrazole induced seizure (scPTZ) models. The quantitative in vivo anticonvulsant evaluation of N-phenylamino-3,3-dimethyl-pyrrolidine-2,5-dione (15), conducted at the time of peak pharmacodynamic activity (TPE), showed the MES ED50 value of 69.89 mg/kg in rats. The median toxic dose (TD50) was 500 mg/kg, providing compound 15 with a protective index (TD50/ED50) of 7.15 in the MES test.