16010-88-1Relevant articles and documents
Photoinduced Vitamin B12-Catalysis for Deprotection of (Allyloxy)arenes
Giedyk, Maciej,Turkowska, Joanna,Lepak, Sandra,Marculewicz, Marcin,ó Proinsias, Keith,Gryko, Dorota
supporting information, p. 2670 - 2673 (2017/05/24)
Vitamin B12 is a natural cobalt complex that, while reduced to the "supernucleophilic" Co(I) form, can easily react with electrophiles via an SN2 mechanism. It is also shown to react via an SN2′ mechanism with allylic compounds allowing for photochemical deprotection of (allyloxy)arenes. A sustainable alternative to commonly used noble metal-catalyzed deprotection reactions is presented.
Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - Development of potential agents for the treatment of Alzheimer's disease
Linning, Philipp,Haussmann, Ute,Beyer, Isaak,Weidlich, Sebastian,Schieb, Heinke,Wiltfang, Jens,Klafki, Hans-Wolfgang,Kn?lker, Hans-Joachim
, p. 8216 - 8235 (2012/11/07)
Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). The Royal Society of Chemis
Aminoalcohol derivatives
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Page/Page column 20, (2010/02/07)
The present invention relates to a compound formula [I]: wherein R1 is hydrogen or halogen, R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, X is bond, —CH2— or —O—, and Y is ?in which R4 is lower alkoxycarbonyl, ?in which R5 is carboxy(lower)alkyl, etc., ?in which R6 is hydroxy, etc., and so on, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.