160194-39-8

Basic information

• Product Name: 2-{5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YL}ETHAAN-1-OL
• Synonyms: 2-{5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YL}ETHAAN-1-OL;2-[5-(1,2,4-Triazol-1-ylmethyl)-1H-indol-3-yl]ethanol;2-(6-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-3-yl)ethanol;5-(1H-1,2,4-triazol-1-ylmethyl)-1H-Indole-3-ethanol
• CAS NO: 160194-39-8
• Molecular Formula: C₁₃H₁₄N₄O
• Molecular Weight: 242.27646
• Mol File: 160194-39-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 545.458 °C at 760 mmHg
• Flash Point: 283.683 °C
• Appearance: /
• Density: 1.35
• PKA: 14.95±0.10(Predicted)
• CAS DataBase Reference: 2-{5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YL}ETHAAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YL}ETHAAN-1-OL(160194-39-8)
• EPA Substance Registry System: 2-{5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YL}ETHAAN-1-OL(160194-39-8)

Safety Data

• Hazardous Substances Data: 160194-39-8(Hazardous Substances Data)

Usage

Description

2-5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YLETHAAN-1-OL, also known as 5-(1H-1,2,4-Triazol-1-ylmethyl)-1H-indole-3-ethanol, is an organic compound that serves as a crucial intermediate in the pharmaceutical industry. It is characterized by its unique molecular structure, which includes a triazole and indole ring, making it a valuable component in the development of various drugs.

Uses

Used in Pharmaceutical Industry:
2-5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YLETHAAN-1-OL is used as an intermediate in the synthesis of Rizatriptan Benzoate (R545000), a selective serotonin 5-HT1D receptor agonist. 2-5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YLETHAAN-1-OL is recognized for its potential as an anti-migraine drug, offering a targeted approach to alleviate the symptoms of migraines by specifically activating the 5-HT1D receptors.
The compound's role in the synthesis of Rizatriptan Benzoate highlights its importance in the development of effective treatments for migraine sufferers. By acting as a key intermediate, 2-5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YLETHAAN-1-OL contributes to the creation of a drug that can provide relief from the debilitating pain associated with migraines, improving the quality of life for many individuals.

Upstream product

• 160194-28-5 1-triethylsilanyl-4-(triethylsilanyloxy)but-1-yne 
• 160194-26-3 4-((1H-1,2,4-triazol-1-yl)methyl)-2-iodobenzenamine 
• 119192-10-8 4-(1H-1,2,4-triazol-1-ylmethyl)aniline 

Downstream Products

• 145202-66-0 rizatriptan benzoate 
• 144034-80-0 rizatriptan 

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