160252-91-5

Basic information

• Product Name: N^α-9-Fluorenylmethyloxycarbonyl-N^G-4-methoxy-3,5-di-tert-butylbenzenesulphonyl-L-arginine
• CAS NO: 160252-91-5
• Molecular Weight: 678.85
• Mol File: 160252-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α-9-Fluorenylmethyloxycarbonyl-N^G-4-methoxy-3,5-di-tert-butylbenzenesulphonyl-L-arginine(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-9-Fluorenylmethyloxycarbonyl-N^G-4-methoxy-3,5-di-tert-butylbenzenesulphonyl-L-arginine(160252-91-5)
• EPA Substance Registry System: N^α-9-Fluorenylmethyloxycarbonyl-N^G-4-methoxy-3,5-di-tert-butylbenzenesulphonyl-L-arginine(160252-91-5)

Safety Data

• Hazardous Substances Data: 160252-91-5(Hazardous Substances Data)

Upstream product

• 160252-87-9 N^α-Benzyloxycarbonyl-N^G-4-methoxy-3,5-di-tert-butylbenzenesulphonyl-L-arginine 
• 160252-94-8 3,5-di-tert-butyl-4-methoxybenzene-1-sulfonyl chloride 
• 1234-35-1 Z-Arg-OH 
• 1516-95-6 2,6-di-tert-butyl-anisole 
• 128-39-2 2,6-di-tert-butylphenol 
• 74-79-3 L-arginine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 91000-69-0 Fmoc-L-Arg-OH 

Relevant articles and documents

Factors Influencing the Acid Lability of Substituted Arylsulphonyl Arginine Protecting Groups

The kinetics of hydrolysis of new, NG-protected 2,4,6-triisopropylbenzene-sulphonyl (6), 4-methoxy-3,5-di-tert-butylbenzenesulphonyl (12) and phenanthrene-3-sulphonyl (17) Fmoc derivatives of L-arginine (1) in comparison with commercially available Fmoc-Arg(Mtr)-OH (Mtr = 4-methoxy-2,3,6-trimethyl-benzenesulphonyl (2)) are studied.The acid lability of the arylsulphonyl group is decreasing as follows Mtr > Tip > Mtbs > Phen.The effect of electron-donating alkyl groups as substituents in increasing the acid lability of the arylsulphonyl residue seems to be in the order of methyl > isopropyl > tert-butyl, while the effect of extended delocalization does not appreciably increase the acid lability. - Keywords: 2,4,6-Triisopropylbenzenesulphonyl (Tip), 4-methoxy-3,5-di-tert-butylbenzenesulphonyl (Mtbs), Phenanthrene-3-sulphonyl (Phen) Residues