160337-95-1

Basic information

• Product Name: insulin glargine
• Synonyms: insulin glargine;A21-Gly-B31-Arg-B32-Arg-insulin;Insulin, glycyl(A21)-arginyl(B31,B32)-;Lantus;Solostar;Solostar [insulin delivery pen];Unii-2zm8cx04rz;Insulin Glargine EP/USP
• CAS NO: 160337-95-1
• Molecular Formula: C267H404N72O78S6
• Molecular Weight: 6062.89026
• Mol File: 160337-95-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C, Inert atmosphere
• Solubility: Aqueous Acid (Very Slightly)
• CAS DataBase Reference: insulin glargine(CAS DataBase Reference)
• NIST Chemistry Reference: insulin glargine(160337-95-1)
• EPA Substance Registry System: insulin glargine(160337-95-1)

Safety Data

• Hazardous Substances Data: 160337-95-1(Hazardous Substances Data)

Usage

Description

Insulin glargine, also known as Lantus, is a long-acting basal insulin analogue derived from human insulin. It is modified by replacing the asparagine residue at position A21 of the A-chain with glycine and adding two arginines to the C-terminus of the B-chain. This modification results in a longer duration of action and a more stable, soluble form of insulin, making it suitable for once-daily administration.

Uses

Used in Diabetes Treatment:
Insulin glargine is used as a long-acting basal insulin analogue for controlling blood sugar levels in individuals with type 1 and type 2 diabetes mellitus. It helps maintain a stable blood glucose level by mimicking the natural release of insulin from the pancreas, providing a steady background level of insulin throughout the day.
Used in Pharmaceutical Industry:
Insulin glargine is used as a key component in the development of various pharmaceutical products for the treatment of diabetes. It is the active ingredient in the brand name medication Lantus, manufactured by Hoechst Marion Roussel. This medication is widely prescribed to adults with type 1 or type 2 diabetes to manage their blood sugar levels effectively.