160343-11-3

Basic information

• Product Name: Rp-3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl 5'-O-dimethoxytritylthymidin-3'-yl phenylphosphonate
• Synonyms: Rp-3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl 5'-O-dimethoxytritylthymidin-3'-yl phenylphosphonate
• CAS NO: 160343-11-3
• Molecular Weight: 1023.16
• Mol File: 160343-11-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Rp-3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl 5'-O-dimethoxytritylthymidin-3'-yl phenylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Rp-3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl 5'-O-dimethoxytritylthymidin-3'-yl phenylphosphonate(160343-11-3)
• EPA Substance Registry System: Rp-3'-O-(tert-butyldimethylsilyl)thymidin-5'-yl 5'-O-dimethoxytritylthymidin-3'-yl phenylphosphonate(160343-11-3)

Safety Data

• Hazardous Substances Data: 160343-11-3(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 133471-17-7 (R_P)-5'-O-(4,4-dimethoxytrityl)-2'-thymidylyl-(3'->5')-3'-O-<1,1-dimethylethyl)dimethylsilyl>-thymidine 3'-H-phosphonate 
• 591-50-4 iodobenzene 

Downstream Products

• 1370586-79-0 C₅₆H₆₆N₆O₁₄P₂ 
• 160400-84-0 (R)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl thymidin-5'-yl phenylphosphonate 

Relevant articles and documents

Preparation of arylphosphonates by palladium(O)-catalyzed cross-coupling in the presence of acetate additives: Synthetic and mechanistic studies

An efficient protocol for the synthesis of arylphosphonate diesters via a palladium-catalyzed cross-coupling of H-phosphonate diesters with aryl electrophiles, promoted by acetate ions, was developed. A significant shortening of the cross-coupling time in the presence of the added acetate ions was achieved for bidentate and monodentate supporting ligands, and for different aryl electrophiles (iodo, bromo and triflate derivatives). The reaction conditions were optimized in terms of amount of the catalyst, supporting ligands, and source of the acetate ion used. Various arylphosphonates, including those of potential biological significance, were synthesized using this newly developed protocol. Some mechanistic aspects of the investigated reactions are also discussed.