160375-37-1

Basic information

• Product Name: 2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid
• Synonyms: 2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid
• CAS NO: 160375-37-1
• Molecular Weight: 307.324
• Mol File: 160375-37-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid(160375-37-1)
• EPA Substance Registry System: 2-Cyclopropyl-4-(4-fluoro-phenyl)-quinoline-3-carboxylic acid(160375-37-1)

Safety Data

• Hazardous Substances Data: 160375-37-1(Hazardous Substances Data)

Upstream product

• 24922-02-9 Ethyl 3-cyclopropyl-3-oxopropionate 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 
• 765-43-5 Cyclopropyl methyl ketone 
• 148516-11-4 2-cyclopropyl-4-(4-fluoro-phenyl)-3-quinoline carboxylic acid ethyl ester 
• 934560-46-0 N-[2-(4-fluorobenzoyl)phenyl]-4-methylbenzenesulfonamide 
• 3800-06-4 2-amino-4'-fluorobenzophenone 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 118-92-3 anthranilic acid 

Downstream Products

• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 153968-97-9 2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline 

Relevant articles and documents

Pitavastatin calcium method for the preparation of intermediates

The invention discloses a preparation method for a pitavastatin calcium intermediate shown in the formula (I) of the Specification. According to the invention, the pitavastatin calcium intermediate is prepared from ester compounds shown in the formula (II) of the Specification through hydrolysis and reduction; alcohol is used as hydrolysis medium, alcoholate can be formed by the alcohol and hydroxide, and the alkalinity of the alcoholate is stronger than that of the hydroxide, so that hydrolysis reaction is relatively facilitated; the hydrolysis time is 3-4 days when the hydrolysis medium in the prior art is an aqueous solution, while the hydrolysis time of the preparation method provided by the invention is less than 20 h.