160377-48-0

Basic information

• Product Name: 5-(4-IODOPHENYL)ISOXAZOLE
• Synonyms: 5-(4-IODOPHENYL)ISOXAZOLE;BUTTPARK 81\09-48
• CAS NO: 160377-48-0
• Molecular Formula: C9H6INO
• Molecular Weight: 271.05
• Mol File: 160377-48-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 139 °C
• Boiling Point: 344.2 °C at 760 mmHg
• Flash Point: 162 °C
• Appearance: /
• Density: 1.773 g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 5-(4-IODOPHENYL)ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-IODOPHENYL)ISOXAZOLE(160377-48-0)
• EPA Substance Registry System: 5-(4-IODOPHENYL)ISOXAZOLE(160377-48-0)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 160377-48-0(Hazardous Substances Data)

Usage

General Description

5-(4-Iodophenyl)isoxazole is a chemical compound with the molecular formula C8H5INO. It is an isoxazole derivative with a phenyl group substituted with an iodine atom at the 4-position. 5-(4-IODOPHENYL)ISOXAZOLE has potential applications in the field of medicinal chemistry and drug development, as isoxazole derivatives have been studied for their pharmacological properties, including anti-inflammatory, analgesic, and antimicrobial activities. The iodine substitution on the phenyl ring may also impart unique chemical and biological properties to the compound, making it a valuable building block for the synthesis of novel pharmaceutical compounds or research tools in the future.

InChI:InChI=1/C9H6INO/c10-8-3-1-7(2-4-8)9-5-6-11-12-9/h1-6H

Downstream Products

• 1428627-90-0 3,17β-bis(hydroxy)-7α-[6-(4-isoxazol-5-yl-phenyl)-hex-5-ynyl]estra-1,3,5(10)-triene 

Relevant articles and documents

Quinuclidine derivatives as squalene synthase inhibitors

Compounds of formula (I) and their pharmaceutically acceptable salts in which R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR1 -CR2 is a double bond; X is selected from --CH2 CH2 --, --CH=CH--, --C C--, --CH2 O--, --CH2 NH--, --NHCH2 --, --CH2 CO--, --COCH2 --, --CH2 S-- and --SCH2 --; Ar1 is a phenylene moiety; Ar2 is a heteroaryl moiety; and wherein one or both of Ar1 and Ar2 may optionally bear one or more substituents independently selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, di-alkylamino, N-alkylcarbamoyl, di-N,N-alkylcarbamoyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, halogeno-alkyl, carboxyalkyl and alkanoylamino; provided that when R1 is hydroxy, X is not selected from --NHCH2 -- and --SCH2 --; are inhibitors of squalene synthase and hence useful in treating medical conditions in which a lowering of cholesterol is beneficial, such as hypercholesterolemia and atherosclerosis. Processes for preparing these derivatives, pharmaceutical compositions containing them are also described together with their use in medicine.