160388-15-8Relevant articles and documents
Iridium-catalyzed 1,3-hydrogen shift/chlorination of allylic alcohols
Ahlsten, Nanna,Gomez, Antonio Bermejo,Martin-Matute, Belen
supporting information, p. 6273 - 6276 (2013/07/05)
Tandem: Allylic alcohols react with N-chlorosuccinimide (NCS) in a tandem 1,3-H shift/C-Cl bond formation leading to α-chloroketones and α-chloroaldehydes. The reactions proceed with complete selectivity to give single constitutional isomers of monochlorinated carbonyl compounds. The utility of the transformation is illustrated by the straightforward synthesis of 4,5-disubstituted 2-aminothiazoles from allylic alcohols. Copyright